Reduction in the The Incidence of Type 2 DM with Lifestyle Intervention or Metformin Study synopsis This is a randomized controlled trial to assess the effects of lifestyle modification and metformin in the prevention of diabetes in high risk individuals. The hypothesis was that lifestyle intervention or metformin would prevent or delay the development of diabetes. 3,234 persons with elevated fasting and post-load glucose concentrations were assigned to receive placebo, receive metformin, or par …
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